Personal Information

Name: Lorenz Thurner

 

Work Experience

2010-2011 Department of Neurology, Medical School

Mainz, Germany, Resident

 

2011 – present Department of Hematology/Oncology and José Carreras Research Center for Immuno and Gene Therapy, Saarland Medical School Homburg/Saar, Germany, Internship in Internal Medicine, Hematology/Oncology and Post-Doc

 

2017 Senior physican

 

Education

2003 – 2009 Studies of Medicine, Saarland Medical School, Homburg/Saar, Germany

 

2004 – 2005 Visiting Student, Leicester Medical School, UK.

 

2007 – 2008 Visiting Scientist, European Doctoral College, Laboratoire d’Immunopathologie, INSERM Equipe 737 “B-cell tolerance and autoimmunity”, Supervisors Prof. Thiery Martin and Prof. Jean-Louis Pasquali, Strasbourg Medical School, France

 

2006 – 2011 Medical thesis, José Carreras Research Center for Immuno and Gene Therapy, Saarland Medical School, Homburg/Saar, Germany. Supervisors: Prof. Dr. Michael Pfreundschuh & Prof. Dr. Jan Voswinkel ”Wegener's granuloma harbors B lymphocytes with specificities against a pro- inflammatory transmembrane protein and a tetraspanin.”

 

Awards/ Fellowships

2010/2011 Eduard-Martin-Award for the best dissertation in the faculty of Medicine, University of Saarland

2011/12 Fellowship for one year research position at the José Carreras Center Homburg/Saar awarded by University of Saarland

2014 ASH Abstract Achievement Award Recipient

 

Invited Reviewer:

FEBS, PLOSone, Clinical Rheumatology

 

Memberships:

German society for Immunology since 2008

German society for Internal Medicine since 2011

German society for Rheumatology since 2012

German society for Hematology and Oncology since 2014

European Hematology Association since 2015

 

Talks / Poster Presentations:

2008

Generation of monoclonal antibodies (mAbs) from Wegener’s granuloma-derived single B lymphocytes using recombinant baculoviruses. Annual Meeting of the Austrian and German Societies of Immunology, Vienna. (Poster)

 

2013

Pro-inflammatory Progranulin antibodies occur in a wide spectrum of autoimmune diseases and are associated with alternative Progranulin conversion. 

Annual Meeting of the German Society of Immunology, Mainz. (Poster)

 

2014

Transient Hyperphosphorylation of Progranulin induces proinflammatory Progranulin Antibodies.

Annual Meeting of the German Society of Immunology, Bonn. (Poster)

 

Autoreactivity of B Cell Receptors of Nodular Lymphocyte Predominant Hodgkin Lymphoma. Annual Meeting of the DGHO, OeGHO, SGMO und SGH 2014, Hamburg. (Poster)

 

Posttranslationally Modified Proteins in the Central Nervous System (CNS) Are the Dominant Antigenic Target/Stimulus of the B-Cell Receptor (BCR) in Primary CNS Lymphomas (PCNSL). 56th ASH Annual Meeting, San Francisco (Talk)

 

2015

Identifikation einer N-Hyperglykosylierten ZNS-Proteindomaine als B-Zell-Rezeptor-Zielantigen beim primären ZNS Lymphom. Annual Meeting of the DGHO, OeGHO, SGMO und SGH 2015, Basel (Talk)

 

A posttranslationally modified autoantigen is the first molecularly defined risk factor and the predominant target antigen of DLBCL of ABC type. Annual Meeting of the DGHO, OeGHO, SGMO, Basel (Talk)

 

Moraxella catarrhalis – the infectious origin of nodular lymphocyte predominant Hodgkin Lymphoma of IgD type? Annual Meeting of the DGHO, OeGHO, SGMO und SGH 2015, Basel (Talk)

 

LRPAP1 Is a Frequent B-Cell Receptor Antigen in Mantle Cell Lymphoma 57th Annual Meeting of the American Society of Hematology Orlando, USA (Poster)

 

2016

LRPAP1, the predominant antigen of mantle cell lymphoma B cell receptors, induces proliferation and serves as a basis for a novel therapeutic strategy with ultimate specificity. Annual Meeting of the DGHO, OeGHO, SGMO und SGH 2016, Leipzig (Talk)

 

B Cell Receptor stimulation in NLPHL. 10th ISHL, Köln, (Talk)

 

Patents

Progranulin as a marker for autoimmune disease

 

Selected Publications

Thurner L, Müller A, Cérutti M, Thierry M, Pasquali J-L, Gross W L, Held G, Assmann G, Pfreundschuh M, Voswinkel J (2010) Wegener’s granuloma harbors B cells with specificities against a proinflammatory transmembrane protein and a tetraspanin Journal of Autoimmunity

 

Thurner L, Preuss KD, Fadle N, Regitz E, Klemm P, Zaks M, Kemele M, Hasenfus A, Csernok E, Gross WL, Pasquali JL, Martin T, Bohle RM, Pfreundschuh M. (2013) Progranulin antibodies in autoimmune diseases. J Autoimmun.

 

Thurner L, Zaks M, Preuss KD, Fadle N, Regitz E, Ong MF, Pfreundschuh M, Assmann G (2013) Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis. Arthritis Res Ther

 

Thurner L, Stöger E, Fadle N, Klemm P, Regitz E, Kemele M, Bette B, Held G, Dauer M, Lammert F, Preuss KD, Zimmer V, Pfreundschuh M (2014) Proinflammatory Progranulin Antibodies in Inflammatory Bowel Diseases. Dig Dis Sci.

 

Thurner L, Fadle N, Regitz E, Kemele M, Klemm P, Zaks M, Stöger E, Bette B, Carbon G, Zimmer V, Assmann G, Murawski N, Kubuschok B, Held G, Preuss KD, Pfreundschuh M. (2015) The molecular basis for development of proinflammatory autoantibodies to progranulin. J Autoimmunity

 

Williams A, Wang EC, Thurner L, Liu CJ. Novel insights into TNF receptor, DR3 and progranulin pathways in arthritis and bone remodeling. Arthritis Rheumatol. 2016 Jul 18. [Epub ahead of print] Review